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Article

Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory.

PloS one - 1 Jan 2015

Hori Kei, Nagai Taku, Shan Wei, Sakamoto Asami, Abe Manabu, Yamazaki Maya, Sakimura Kenji, Yamada Kiyofumi, Hoshino Mikio

Abstract excerpt

Mutations in the Autism susceptibility candidate 2 gene (AUTS2) have been associated with a broad range of psychiatric illnesses including autism spectrum disorders, intellectual disability and schizophrenia. We previously demonstrated that the cytoplasmic AUTS2 acts as an upstream factor for the Rho family small GTPase Rac1 and Cdc42 that regulate the cytoskeletal rearrangements in neural cells. Moreover,...

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Source

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Identifiers

PMID: 26717414
DOI: 10.1371/journal.pone.0145979
PMCID: PMC4699902

Genes

AUTS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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