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Article

NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation

1 Jun 2018

Abstract excerpt

Netrin-G ligand 2 (NGL-2)/LRRC4, implicated in autism spectrum disorders and schizophrenia, is a leucine-rich repeat-containing postsynaptic adhesion molecule that interacts intracellularly with the excitatory postsynaptic scaffolding protein PSD-95 and trans -synaptically with the presynaptic adhesion molecule netrin-G2. Functionally, NGL-2 regulates excitatory synapse development and synaptic transmission....

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PMID: 29949768
DOI: 10.1016/j.celrep.2018.05.087

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