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Article

Evaluation of Pax6 mutant rat as a model for autism.

PloS one - 21 Dec 2010

Umeda Toshiko, Takashima Noriko, Nakagawa Ryoko, Maekawa Motoko, Ikegami Shiro, Yoshikawa Takeo, Kobayashi Kazuto, Okanoya Kazuo, Inokuchi Kaoru, Osumi Noriko

Abstract excerpt

Autism is a highly variable brain developmental disorder and has a strong genetic basis. Pax6 is a pivotal player in brain development and maintenance. It is expressed in embryonic and adult neural stem cells, in astrocytes in the entire central nervous system, and in neurons in the olfactory bulb, amygdala, thalamus, and cerebellum, functioning in highly context-dependent manners. We have recently reported that...

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PMID: 21203536
DOI: 10.1371/journal.pone.0015500
PMCID: PMC3006426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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