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Metabolomics to unveil and understand phenotypic diversity between pathogen populations.

PLoS neglected tropical diseases - 30 Nov 2010

t'Kindt Ruben, Scheltema Richard A, Jankevics Andris, Brunker Kirstyn, Rijal Suman, Dujardin Jean-Claude, Breitling Rainer, Watson David G, Coombs Graham H, Decuypere Saskia

Abstract excerpt

Leishmaniasis is a debilitating disease caused by the parasite Leishmania. There is extensive clinical polymorphism, including variable responsiveness to treatment. We study Leishmania donovani parasites isolated from visceral leishmaniasis patients in Nepal that responded differently to antimonial treatment due to differing intrinsic drug sensitivity of the parasites. Here, we present a proof-of-principle study...

Topics

Antiprotozoal Agents
Biodiversity
Drug Resistance
Humans
Leishmania donovani
Leishmaniasis, Visceral
Mass Spectrometry
Metabolomics
Phenotype
Protozoan Proteins

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Identifiers

PMID: 21152055
DOI: 10.1371/journal.pntd.0000904
PMCID: PMC2994915

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