Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.

PLoS neglected tropical diseases - 1 Jan 2012

Decuypere Saskia, Vanaerschot Manu, Brunker Kirstyn, Imamura Hideo, Müller Sylke, Khanal Basudha, Rijal Suman, Dujardin Jean-Claude, Coombs Graham H

Abstract excerpt

The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is universal for the studied pathogen; it has seldom been clarified whether drug-resistance mechanisms vary with the pathogen's genotype. Nevertheless this is of critical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiprotozoal Agents
Share to DNA, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Gene Expression Profiling

Share to Leishmania donovani

Share to Leishmaniasis, Visceral

Share to Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22389733
DOI: 10.1371/journal.pntd.0001514
PMCID: PMC3289598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.PMID 22389733Read ↗

(Post-) Genomic approaches to tackle drug resistance in Leishmania.Semantic proximity Read ↗

Integrative genomic, proteomic and phenotypic studies of Leishmania donovani strains revealed genetic features associated with virulence and antimony-resistance.Semantic proximity Read ↗

Role of efflux pumps and intracellular thiols in natural antimony resistant isolates of Leishmania donovani.Semantic proximity Read ↗

Epidemiological Insights: Unraveling Drug Resistance in Leishmania Species through Comprehensive StudiesSemantic proximity Read ↗

Antimony resistance and gene expression in Leishmania : spotlight on molecular and proteomic aspectsSemantic proximity Read ↗

Unravelling drug resistance in leishmaniasis: genomic adaptations and emerging therapiesSemantic proximity Read ↗

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs.Semantic proximity Read ↗

Biomarkers of antimony resistance: need for expression analysis of multiple genes to distinguish resistance phenotype in clinical isolates of Leishmania donovaniSemantic proximity Read ↗

Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent.Semantic proximity Read ↗

Drug resistance analysis by next generation sequencing in Leishmania.Semantic proximity Read ↗

Epidemiological dynamics of antimonial resistance in Leishmania donovani: genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal.Semantic proximity Read ↗

Understanding drug resistance in malaria parasites: Basic science for public healthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.