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Article

Metabolic adaptations of Leishmania donovani in relation to differentiation, drug resistance, and drug pressure.

Molecular microbiology - 1 Oct 2013

Berg Maya, Vanaerschot Manu, Jankevics Andris, Cuypers Bart, Maes Ilse, Mukherjee Sandip, Khanal Basudha, Rijal Suman, Roy Syamal, Opperdoes Fred, Breitling Rainer, Dujardin Jean-Claude

Abstract excerpt

Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closely linked in Leishmania donovani, with SSG-resistant strains showing an increased capacity to generate infectious (metacyclic) forms. This is the first untargeted LC-MS metabolomics study which integrated both phenomena in one experimental design and provided insights into metabolic differences between three clinical...

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PMID: 24020363
DOI: 10.1111/mmi.12374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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