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Article

Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent.

mSphere - 25 Apr 2018

Dumetz F, Cuypers B, Imamura H, Zander D, D'Haenens E, Maes I, Domagalska M A, Clos J, Dujardin J-C, De Muylder G

Abstract excerpt

Antimonials (Sb) were used for decades for chemotherapy of visceral leishmaniasis (VL). Now abandoned in the Indian subcontinent (ISC) because of Leishmania donovani resistance, this drug offers a unique model for understanding drug resistance dynamics. In a previous phylogenomic study, we found two distinct populations of L. donovani: the core group (CG) in the Gangetic plains and ISC1 in the Nepalese highlands....

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Identifiers

PMID: 29669889
DOI: 10.1128/mSphere.00548-17
PMCID: PMC5907651

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