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Article

Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.

Molecular cell - 7 Jan 2016

Zhang Yongping, Liu Xiaoman, Bai Jian, Tian Xuejun, Zhao Xiaocui, Liu Wei, Duan Xiuying, Shang Weina, Fan Heng-Yu, Tong Chao

Abstract excerpt

Mitochondria undergo frequent morphological changes through fission and fusion. Mutations in core members of the mitochondrial fission/fusion machinery are responsible for severe neurodegenerative diseases. However, the mitochondrial fission/fusion mechanisms are poorly understood. We found that the loss of a mitochondrial protein encoding gene, mitoguardin (miga), leads to mitochondrial defects and...

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Source

Identifiers

PMID: 26711011
DOI: 10.1016/j.molcel.2015.11.017

Genes

MIGA1
MIGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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