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Article

Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors.

Cancer research - 1 Jul 2008

Feitsma Harma, Kuiper Raoul V, Korving Jeroen, Nijman Isaac J, Cuppen Edwin

Abstract excerpt

Defective mismatch repair (MMR) in humans causes hereditary nonpolyposis colorectal cancer. This genetic predisposition to colon cancer is linked to heterozygous familial mutations, and loss-of-heterozygosity is necessary for tumor development. In contrast, the rare cases with biallelic MMR mutations are juvenile patients with brain tumors, skin neurofibromas, and café-au-lait spots, resembling the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18593904
DOI: 10.1158/0008-5472.CAN-08-0019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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