Article
Development of new quantitative mass spectrometry and semi-automatic isofocusing methods for the determination of Apolipoprotein E typing.
Clinica chimica acta; international journal of clinical chemistry - 15 Feb 2016
Hirtz Christophe, Vialaret Jerome, Nouadje Georges, Schraen Susanna, Benlian Pascale, Mary Sandrine, Philibert Pascal, Tiers Laurent, Bros Pauline, Delaby Constance, Gabelle Audrey, Lehmann Sylvain
Abstract excerpt
BACKGROUND: Apolipoprotein E (Apo E) is a 36 Kda glycoprotein involved in lipid transport. It exists in 3 major isoforms: E2, E3 and E4. ApoE status is known to be a major risk factor for late-onset Alzheimer's and cardiovascular diseases. Genotyping is commonly used to obtain ApoE status but can show technical issues with ambiguous determinations. Phenotyping can be an alternative, not requiring genetic...
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