Article
Validation of a novel and accurate ApoE4 assay for automated chemistry analyzers.
Scientific reports - 7 Feb 2020
Veiga Sergio, Rodríguez-Martín Andrés, Garcia-Ribas Guillermo, Arribas Ignacio, Menacho-Román Miriam, Calero Miguel
Abstract excerpt
The allele ε4 of the apolipoprotein E gene (APOE ε4) is the major genetic risk factor for non-dominantly inherited Alzheimer's Disease (AD). Current techniques for APOE ε4 carriers identification show good accuracy but have several disadvantages that limit its implementation in a clinical laboratory. These include the need for sample preprocessing, poor automation, low throughput, requirement of additional...
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