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Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents

23 Dec 2015

Abstract excerpt

Dicer participates in heterochromatin formation in fission yeast and plants. However, whether it has a similar role in mammals remains controversial. Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm. Dicer knockdown led to an increase of chromatin-associated SIRT7 and...

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PMID: 26704979
DOI: 10.1093/nar/gkv1504

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