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Article

A positive feedback loop of SIRT1 and miR17HG promotes the repair of DNA double-stranded breaks

10 Jul 2019

Abstract excerpt

Long noncoding RNAs (lncRNAs) have emerged as critical regulators for gene expression in multiple levels and thus are involved in various physiological and pathological processes. Sirtuin 1 (SIRT1) has been established to exert key roles in the diverse biological process through deacetylation of substrates, including DNA damage repair. Nevertheless, the regulatory relationship between SIRT1 and lncRNAs, and the...

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PMID: 31290724
DOI: 10.1080/15384101.2019.1641388

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