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Article

Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis

28 Aug 2007

Abstract excerpt

The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase. Here we report that SIRT2 maintains a largely cytoplasmic localization during interphase by active nuclear export in a Crm1-dependent manner. We identified a functional, leptomycin B-sensitive, nuclear export signal sequence within SIRT2. During the cell cycle, SIRT2 becomes...

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PMID: 17726514
DOI: 10.1371/journal.pone.0000784

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