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Article

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.

Nature - 5 Jul 2012

Barber Matthew F, Michishita-Kioi Eriko, Xi Yuanxin, Tasselli Luisa, Kioi Mitomu, Moqtaderi Zarmik, Tennen Ruth I, Paredes Silvana, Young Nicolas L, Chen Kaifu, Struhl Kevin, Garcia Benjamin A, Gozani Or, Li Wei, Chua Katrin F

Abstract excerpt

Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism and ageing. SIRT7 is a mammalian sirtuin whose biochemical activity, molecular targets and physiological functions have been unclear. Here we show that SIRT7 is an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells. Genome-wide binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22722849
DOI: 10.1038/nature11043
PMCID: PMC3412143

Genes

SIRT7
ELK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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