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Article

SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis

15 Aug 2020

Abstract excerpt

SIRT7 is a member of the mammalian sirtuins and functions as an NAD + -dependent deacylase. Here we show that SIRT7 deficiency leads to a lowered histone acetyltransferase 1 (HAT1) activity and therefore decreased histone H4K5 and H4K12 acetylation. This in turn causes CENP-A dislocation at the centromere, which further affects chromatin assembly. SIRT7 ablation results in aneuploidy and aging phenotypes,...

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PMID: 32861997
DOI: 10.1016/j.isci.2020.101461

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