Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dicer regulates non-homologous end joining and is associated with chemosensitivity in colon cancer patients

24 Jun 2017

Abstract excerpt

DNA double-strand break (DSB) repair is an important mechanism underlying chemotherapy resistance in human cancers. Dicer participates in DSB repair by facilitating homologous recombination. However, whether Dicer is involved in non-homologous end joining (NHEJ) remains unknown. Here, we addressed whether Dicer regulates NHEJ and chemosensitivity in colon cancer cells. Using our recently developed NHEJ assay, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genomics, phytochemicals, and oxidative stress
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28911000
DOI: 10.1093/carcin/bgx059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Dicer regulates non-homologous end joining and is associated with chemosensitivity in colon cancer patientsPMID 28911000Read ↗

Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agentsSemantic proximity Read ↗

Genome-wide RNAi Screening Identifies RFC4 as a Factor That Mediates Radioresistance in Colorectal Cancer by Facilitating Nonhomologous End Joining RepairSemantic proximity Read ↗

Reduction of H3K27cr Modification During DNA Damage in Colon CancerSemantic proximity Read ↗

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.Semantic proximity Read ↗

Advances in DNA damage response inhibitors in colorectal cancer therapySemantic proximity Read ↗

A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell CancerSemantic proximity Read ↗

A Potential Prognosis and Immune Biomarker in Cancer: DICER1Semantic proximity Read ↗

Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.