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Article

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

20 Jul 2016

Abstract excerpt

Although SIRT7 is a member of sirtuin family proteins that are described as NAD(+)-dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein remains to be investigated and the cellular function of SIRT7 remains to be explored. Here we report that SIRT7 is an NAD(+)-dependent histone desuccinylase. We show that SIRT7 is recruited to DNA double-strand breaks (DSBs) in a...

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PMID: 27436229
DOI: 10.1038/ncomms12235

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