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Article

Role of tRNA amino acid-accepting end in aminoacylation and its quality control.

Nucleic acids research - 1 Nov 2011

Zhou Xiao-Long, Du Dao-Hai, Tan Min, Lei Hui-Yan, Ruan Liang-Liang, Eriani Gilbert, Wang En-Duo

Abstract excerpt

Aminoacyl-tRNA synthetases (aaRSs) are remarkable enzymes that are in charge of the accurate recognition and ligation of amino acids and tRNA molecules. The greatest difficulty in accurate aminoacylation appears to be in discriminating between highly similar amino acids. To reduce mischarging of tRNAs by non-cognate amino acids, aaRSs have evolved an editing activity in a second active site to cleave the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21775341
DOI: 10.1093/nar/gkr595
PMCID: PMC3203616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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