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Article

Oxygenation cascade analysis in conversion of n-octane catalyzed by cytochrome P450 CYP102A3 mutants at the P331 site.

Biotechnology and applied biochemistry - 1 Jan 2017

Wang Songhe, Liu Zhibin

Abstract excerpt

To improve the hydroxylation efficiency of cytochrome P450 CYP102A3 to substrate n-octane, a previously reported triple-mutant F88V/S188Q/A330V with altered regioselectivity was selected and site-saturation mutagenesis was performed at its P331 site, which is adjacent to one of the active sites A330. Using whole-cell biotransformations to analyze the created mutants, four better mutants P331A, P331T, P331S, and...

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PMID: 26704938
DOI: 10.1002/bab.1472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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