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Article

Engineering towards nitroreductase functionality in ene-reductase scaffolds.

Chembiochem : a European journal of chemical biology - 23 Mar 2015

Park Jonathan T, Gómez Ramos Lizzette M, Bommarius Andreas S

Abstract excerpt

Nitroreductases (NRs) and ene-reductases (ERs) both utilize flavin mononucleotide cofactors but catalyze distinct reactions. NRs reduce nitroaromatics, whereas ERs reduce unsaturated C=C double bonds, and these functionalities are known to somewhat overlap. Recent studies on the ER xenobiotic reductase A (XenA) from Pseudomonas putida demonstrated the possibility of increasing NR activity with active site...

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PMID: 25703443
DOI: 10.1002/cbic.201402667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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