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Article

NYX (nyctalopin on chromosome X), the gene mutated in congenital stationary night blindness, encodes a cell surface protein.

Investigative ophthalmology & visual science - 1 Oct 2003

Zeitz Christina, Scherthan Harry, Freier Susanne, Feil Silke, Suckow Vanessa, Schweiger Susann, Berger Wolfgang

Abstract excerpt

PURPOSE: The complete type of X-linked congenital stationary night blindness (CSNB1) in human and mouse is caused by mutations in the NYX gene. The human NYX protein has been predicted to contain an N-terminal endoplasmic reticulum (ER) signaling sequence and a C-terminal glycosylphosphatidylinositol (GPI) anchor. In the current study, these computer predictions were verified experimentally by expression of...

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Source

Identifiers

PMID: 14507859
DOI: 10.1167/iovs.03-0251

Genes

NYX
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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NYX (nyctalopin on chromosome X), the gene mutated in congenital stationary night blindness, encodes a cell surface protein.PMID 14507859Read ↗

Isolation and characterization of the leucine-rich proteoglycan nyctalopin gene (cNyx) from chick.Semantic proximity Read ↗

Identification of the gene and the mutation responsible for the mouse nob phenotype.Semantic proximity Read ↗

Mutations in NYX of individuals with high myopia, but without night blindness.Semantic proximity Read ↗

Novel frameshift mutation in NYX gene in a Russian family with complete congenital stationary night blindness.Semantic proximity Read ↗

Congenital stationary night blindness in mice - a tale of two Cacna1f mutants.Semantic proximity Read ↗

CSNB1 in Chinese families associated with novel mutations in NYX.Semantic proximity Read ↗

A novel missense mutation in the NYX gene associated with high myopia.Semantic proximity Read ↗

Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1.Semantic proximity Read ↗

A common NYX mutation in Flemish patients with X linked CSNB.Semantic proximity Read ↗

NYX-related Congenital Stationary Night Blindness in Two Siblings due to Probable Maternal Germline Mosaicism.Semantic proximity Read ↗

NYX mutations in four families with high myopia with or without CSNB1.Semantic proximity Read ↗

Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness.Semantic proximity Read ↗

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