Co-invalidation of Prnp and Sprn in FVB/N mice affects reproductive performances and highlight complex biological relationship between PrP and Shadoo.

doi:10.1016/j.bbrc.2021.03.013

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Co-invalidation of Prnp and Sprn in FVB/N mice affects reproductive performances and highlight complex biological relationship between PrP and Shadoo.

Biochemical and biophysical research communications - 30 Apr 2021

Castille Johan, Passet Bruno, Makhzami Samira, Vilotte Marthe, Moazami-Goudarzi Katayoun, Truchet Sandrine, Daniel-Carlier Nathalie, Gaillard Anne-Laure, Andréoletti Olivier, Vaiman Daniel, Beauvallet Christian, Vaiman Anne, Floriot Sandrine, Calvel Pierre, Mouillet-Richard Sophie, Duchesne Amandine, Béringue Vincent, Vilotte Jean-Luc

Abstract excerpt

Shadoo and PrP belongs to the same protein family, whose biological function remains poorly understood. Previous experiments reported potential functional redundancies or antagonisms between these two proteins, depending on the tissue analysed. While knockdown experiments suggested the requirement of Shadoo in the absence of PrP during early mouse embryogenesis, knockout ones, on the contrary, highlighted little...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Genes, Lethal

Share to GPI-Linked Proteins

Share to Lactation

Share to Placentation

Share to Prion Proteins

Share to Reproduction

Source

Open in PubMed

Identifiers

PMID: 33713980
DOI: 10.1016/j.bbrc.2021.03.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Co-invalidation of Prnp and Sprn in FVB/N mice affects reproductive performances and highlight complex biological relationship between PrP and Shadoo.PMID 33713980Read ↗

The prion protein family: diversity, rivalry, and dysfunction.Semantic proximity Read ↗

Prion gene paralogs are dispensable for early zebrafish development and have nonadditive roles in seizure susceptibility.Semantic proximity Read ↗

Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science.Semantic proximity Read ↗

The Complex and Diverse Genetic Architecture of the Absence of Horns (Polledness) in Domestic Ruminants, including Goats and Sheep.Semantic proximity Read ↗

PrPs: Proteins with a purpose: Lessons from the zebrafish.Semantic proximity Read ↗

Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice.Semantic proximity Read ↗

Essential role of synoviolin in embryogenesis.Semantic proximity Read ↗

Knock-out mouse models of proprotein convertases: unique functions or redundancy?Semantic proximity Read ↗

Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene.Semantic proximity Read ↗

New insights into form and function of fibronectin splice variants.Semantic proximity Read ↗

Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development.Semantic proximity Read ↗

Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.