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Article

A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions.

Nucleic acids research - 1 Jun 2009

Maitra Radhashree, Sadofsky Moshe J

Abstract excerpt

More than one-third of the RAG1 protein can be truncated from the N-terminus with only subtle effects on the products of V(D)J recombination in vitro or in a mouse. What, then, is the function of the N-terminal domain? We believe it to be regulatory. We determined, several years ago, that an included RING motif could function as an ubiquitin E3 ligase. Whether this activity is limited to automodification, or may...

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Source

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Identifiers

PMID: 19324890
DOI: 10.1093/nar/gkp192
PMCID: PMC2691831

Genes

RAG1
KPNA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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