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Article

DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities.

Aging - 1 Jun 2012

Tadokoro Takashi, Kulikowicz Tomasz, Dawut Lale, Croteau Deborah L, Bohr Vilhelm A

Abstract excerpt

Werner protein (WRN), member of the RecQ helicase family, is a helicase and exonuclease, and participates in multiple DNA metabolic processes including DNA replication, recombination and DNA repair. Mutations in the WRN gene cause Werner syndrome, associated with premature aging, genome instability and cancer predisposition. The RecQ C-terminal (RQC) domain of WRN, containing α2-α3 loop and β-wing motifs, is...

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Share to Catalytic Domain
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22713343
DOI: 10.18632/aging.100463
PMCID: PMC3409678

Genes

WRN
NEIL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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