Article

Germline genomic and methylomic dynamics following three generations of early-life metabolic challenges

2026-07-24

Abstract excerpt

Environmental and dietary factors can exert multigenerational effects on health and development. In this study, we investigated whether early-life metabolic challenge affects the germline genome and epigenome across three generations. Using a murine model of early life obesity via litter size reduction (overnutrition group, ON) and a control group (CT), we followed the paternal lineage focusing on germline genomic...

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Literature Corpus work: 24f3951c-5944-5f58-a39c-8a52f6f15558
DOI: 10.64898/2026.07.21.739755

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