Article
Paternal diet defines offspring chromatin state and intergenerational obesity.
Cell - 4 Dec 2014
Öst Anita, Lempradl Adelheid, Casas Eduard, Weigert Melanie, Tiko Theodor, Deniz Merdin, Pantano Lorena, Boenisch Ulrike, Itskov Pavel M, Stoeckius Marlon, Ruf Marius, Rajewsky Nikolaus, Reuter Gunter, Iovino Nicola, Ribeiro Carlos, Alenius Mattias, Heyne Steffen, Vavouri Tanya, Pospisilik J Andrew
Abstract excerpt
The global rise in obesity has revitalized a search for genetic and epigenetic factors underlying the disease. We present a Drosophila model of paternal-diet-induced intergenerational metabolic reprogramming (IGMR) and identify genes required for its encoding in offspring. Intriguingly, we find that as little as 2 days of dietary intervention in fathers elicits obesity in offspring. Paternal sugar acts as a...
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