Article
TERT promoter hotspot mutations in breast cancer.
Breast cancer (Tokyo, Japan) - 1 May 2018
Shimoi Tatsunori, Yoshida Masayuki, Kitamura Yuka, Yoshino Tomomi, Kawachi Asuka, Shimomura Akihiko, Noguchi Emi, Yunokawa Mayu, Yonemori Kan, Shimizu Chikako, Kinoshita Takayuki, Ichimura Koichi, Fukuda Takahiro, Fujiwara Yasuhiro, Tamura Kenji
Abstract excerpt
BACKGROUND: Telomerase reverse transcriptase (TERT) promoter mutations have been discovered in solid and hematological malignancies, where they reflect TERT activation and cell-cycle progression. In melanoma, glioma, and thyroid cancers, TERT promoter mutations are associated with a poor prognosis. However, no studies have evaluated the prevalence and prognostic significance of TERT promoter mutations in breast...
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