Article
Enhanced OXPHOS, glutaminolysis and β-oxidation constitute the metastatic phenotype of melanoma cells.
The Biochemical journal - 15 Mar 2016
Rodrigues Mariana F, Obre Emilie, de Melo Fabiana H M, Santos Gilson C, Galina Antonio, Jasiulionis Miriam G, Rossignol Rodrigue, Rumjanek Franklin D, Amoêdo Nivea D
Abstract excerpt
Tumours display different cell populations with distinct metabolic phenotypes. Thus, subpopulations can adjust to different environments, particularly with regard to oxygen and nutrient availability. Our results indicate that progression to metastasis requires mitochondrial function. Our research, centered on cell lines that display increasing degrees of malignancy, focused on metabolic events, especially those...
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