Article

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis

2021-11-12

Abstract excerpt

The pentose phosphate pathway is a major source of NADPH for oxidative stress resistance in cancer cells but there is limited insight into its role in metastasis, when some cancer cells experience high levels of oxidative stress. To test this, we mutated the substrate binding site of Glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the first step of the pentose phosphate pathway, in patient-derived melano...

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Literature Corpus work: 88b4d5d4-3c25-51b0-a8d5-074008aa7831
DOI: 10.1101/2021.11.11.468286

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