Article
Therapeutic implications of the metabolic changes associated with BRAF inhibition in melanoma.
Cancer treatment reviews - 1 Sept 2024
Loftus Alexander W, Zarei Mehrdad, Kakish Hanna, Hajihassani Omid, Hue Jonathan J, Boutros Christina, Graor Hallie J, Nakazzi Faith, Bahlibi Tsegaw, Winter Jordan M, Rothermel Luke D
Abstract excerpt
Melanoma metabolism can be reprogrammed by activating BRAF mutations. These mutations are present in up to 50% of cutaneous melanomas, with the most common being V600E. BRAF mutations augment glycolysis to promote macromolecular synthesis and proliferation. Prior to the development of targeted anti-BRAF therapies, these mutations were associated with accelerated clinical disease in the metastatic setting....
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