Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors.

Biochimica et biophysica acta. General subjects - 1 Apr 2018

Marchetti Philippe, Trinh Anne, Khamari Raeeka, Kluza Jerome

Abstract excerpt

BACKGROUND: Besides its influence on survival, growth, proliferation, invasion and metastasis, cancer cell metabolism also greatly influences the cellular responses to molecular-targeted therapies. SCOPE OF THE REVIEW: To review the recent advances in elucidating the metabolic effects of BRAF and MEK inhibitors (clinical inhibitors of the MAPK/ERK pathway) in melanoma and discuss the underlying mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Autophagy
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

Share to Melanoma

Share to Mitochondria

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 29413908
DOI: 10.1016/j.bbagen.2018.01.018

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors.PMID 29413908Read ↗

Therapeutic implications of the metabolic changes associated with BRAF inhibition in melanoma.Semantic proximity Read ↗

Melanoma Metabolism: Molecular Mechanisms and Therapeutic Implications in Cutaneous OncologySemantic proximity Read ↗

Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation.Semantic proximity Read ↗

Role of mitochondria and potential of mitochondria-targeted therapy in BRAF mutant cancer: A review.Semantic proximity Read ↗

New insight into the role of metabolic reprogramming in melanoma cells harboring BRAF mutations.Semantic proximity Read ↗

Mitochondrial oxidative phosphorylation in cutaneous melanomaSemantic proximity Read ↗

Metabolic rewiring directs melanoma immunologySemantic proximity Read ↗

Metabolic rewiring in melanoma.Semantic proximity Read ↗

The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4Semantic proximity Read ↗

Metabolic Reprogramming in Melanoma: An Epigenetic Point of ViewSemantic proximity Read ↗

Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition.Semantic proximity Read ↗

Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.