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Article

Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation.

Cell cycle (Georgetown, Tex.) - 17 Jul 2016

Peppicelli Silvia, Toti Alessandra, Giannoni Elisa, Bianchini Francesca, Margheri Francesca, Del Rosso Mario, Calorini Lido

Abstract excerpt

Low extracellular pH promotes in melanoma cells a malignant phenotype characterized by an epithelial-to-mesenchymal transition (EMT) program, endowed with mesenchymal markers, high invasiveness and pro-metastatic property. Here, we demonstrate that melanoma cells exposed to an acidic extracellular microenvironment, 6.7±0.1, shift to an oxidative phosphorylation (Oxphos) metabolism. Metformin, a biguanide commonly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27266957
DOI: 10.1080/15384101.2016.1191706
PMCID: PMC4968910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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