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Article

PGC1-α-driven mitochondrial biogenesis contributes to a cancer stem cell phenotype in melanoma.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jan 2024

Fontana Fabrizio, Macchi Chiara, Anselmi Martina, Rizzuto Alessandra Stefania, Ruscica Massimiliano, Limonta Patrizia

Abstract excerpt

Little is known about the metabolic regulation of cancer stem cells (CSCs) in melanoma. Here, we used A375 and WM115 cell lines to dissect the role of mitochondria in conferring CSC traits. Notably, we observed that A375 and WM115 melanospheres, known to be enriched in ABCG2+ CSCs, showed higher mitochondrial mass compared with their adherent counterpart. In particular, they displayed increased PGC1-α expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37758066
DOI: 10.1016/j.bbadis.2023.166897

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