Article
Genetic and environmental influences interact with age and sex in shaping the human methylome.
Nature communications - 7 Apr 2016
van Dongen Jenny, Nivard Michel G, Willemsen Gonneke, Hottenga Jouke-Jan, Helmer Quinta, Dolan Conor V, Ehli Erik A, Davies Gareth E, van Iterson Maarten, Breeze Charles E, Beck Stephan, Suchiman H Eka, Jansen Rick, van Meurs Joyce B, Heijmans Bastiaan T, Slagboom P Eline, Boomsma Dorret I
Abstract excerpt
The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to...
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