Article
CC chemokine receptor 1 enhances susceptibility to Leishmania major during early phase of infection.
Immunology and cell biology - 1 Apr 2003
Rodriguez-Sosa Miriam, Rosas Lucia E, Terrazas Luis I, Lu Bao, Gerard Craig, Satoskar Abhay R
Abstract excerpt
CC chemokine receptor 1 (CCR1) is expressed on the surfaces of monocytes, lymphocytes, neutrophils and eosinophils. CC chemokine receptor 1 not only regulates leucocyte chemotaxis, but also plays a role in the regulation of Th1/Th2 cytokine responses. To determine the role of CCR1 in regulation of immune response during Leishmania major infection, we analysed the course of cutaneous L. major infection in...
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