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Article

IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015

Shimizu Kenji, Nakajima Akiko, Sudo Katsuko, Liu Yang, Mizoroki Atsuhiko, Ikarashi Tetsuro, Horai Reiko, Kakuta Shigeru, Watanabe Toshiki, Iwakura Yoichiro

Abstract excerpt

IL-1α and IL-1β (in this article referred to as IL-1) play important roles in host defense against infection and inflammatory diseases. IL-1R1 is the receptor for IL-1, and IL-1R2 is suggested to be a decoy receptor, because it lacks the signal-transducing TIR domain in the cytoplasmic part. However, the roles of IL-1R2 in health and disease remain largely unknown. In this study, we generated EGFP-knock-in...

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Identifiers

PMID: 25725107
DOI: 10.4049/jimmunol.1402155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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