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Article

Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2016

Tracy Timothy S, Chaudhry Amarjit S, Prasad Bhagwat, Thummel Kenneth E, Schuetz Erin G, Zhong Xiao-Bo, Tien Yun-Chen, Jeong Hyunyoung, Pan Xian, Shireman Laura M, Tay-Sontheimer Jessica, Lin Yvonne S

Abstract excerpt

The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human drug metabolism. Alterations in the expression and/or activity of these enzymes result in changes in pharmacokinetics (and consequently the pharmacodynamics) of drugs that are metabolized by this set of enzymes. Apart from changes in activity as a result of drug-drug interactions (by P450 induction or inhibition), the P450...

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Identifiers

PMID: 26681736
DOI: 10.1124/dmd.115.067900
PMCID: PMC4767386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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