Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of Drug-Metabolizing Enzymes: A Path to the Discovery of Multiple Cytochromes P450

22 Jan 2003

Abstract excerpt

This article provides a personal account of the discovery of the induced synthesis of drug-metabolizing enzymes and of subsequent research that led to the discovery of multiple cytochromes P450 with different catalytic activities. The manuscript also emphasizes the role of environmental factors (in addition to genetic polymorphisms) in explaining person-to-person and day-to-day differences in rates and pathways...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug-Induced Hepatotoxicity and Protection
Share to Drug Transport and Resistance Mechanisms
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12540740
DOI: 10.1146/annurev.pharmtox.43.100901.135754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of Drug-Metabolizing Enzymes: A Path to the Discovery of Multiple Cytochromes P450PMID 12540740Read ↗

Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters.Semantic proximity Read ↗

Genetics, epigenetics, and regulation of drug-metabolizing cytochrome p450 enzymes.Semantic proximity Read ↗

Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?Semantic proximity Read ↗

The biochemistry of drug metabolism--an introduction: part 6. Inter-individual factors affecting drug metabolism.Semantic proximity Read ↗

Bench to bedside: Pharmacogenomics, adverse drug interactions, and the cytochrome P450 system.Semantic proximity Read ↗

The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative EnzymesSemantic proximity Read ↗

Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.Semantic proximity Read ↗

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.Semantic proximity Read ↗

Cytochrome p450 part 3: drug interactions: essential concepts and considerations.Semantic proximity Read ↗

Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effectsSemantic proximity Read ↗

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO)Semantic proximity Read ↗

Sources of interindividual variability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.