Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2005

Tang Cuyue, Lin Jiunn H, Lu Anthony Y H

Abstract excerpt

Individual variability in cytochrome P450 (P450) induction comprises an important component contributing to the difficulties in assessing and predicting metabolism-based drug-drug interactions in humans. In this article, we outline the major factors responsible for the individual variability in P450 induction, including variable transporter activity and metabolism of inducers in vivo, genetic variations of P450...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 Enzyme System
Share to Drug Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Induction

Share to Genetic Variation

Share to Pharmaceutical Preparations

Source

Identifiers

PMID: 15673596
DOI: 10.1124/dmd.104.003236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?PMID 15673596Read ↗

Origins of individual variability in P4501A induction.Semantic proximity Read ↗

Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.Semantic proximity Read ↗

Induction of Drug-Metabolizing Enzymes: A Path to the Discovery of Multiple Cytochromes P450Semantic proximity Read ↗

Sources of interindividual variability.Semantic proximity Read ↗

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.Semantic proximity Read ↗

The Influence of Genetic Variations and Drug Interactions Based on Metabolism of Antidepressants and Anticonvulsants.Semantic proximity Read ↗

Pharmacokinetic and pharmacodynamic variability: a daunting challenge in drug therapy.Semantic proximity Read ↗

CYP induction-mediated drug interactions: in vitro assessment and clinical implications.Semantic proximity Read ↗

The biochemistry of drug metabolism--an introduction: part 6. Inter-individual factors affecting drug metabolism.Semantic proximity Read ↗

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in manSemantic proximity Read ↗

Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs.Semantic proximity Read ↗

The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.