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Article

Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs.

The American journal of medicine - 15 Dec 2002

Rogers Janyce F, Nafziger Anne N, Bertino Joseph S

Abstract excerpt

Drug-metabolizing enzyme activity is one of many factors affecting patient response to medications. The objective of this review is to highlight the potential for genetic variability in cytochrome P450 enzyme activity that can lead to interperson differences in response to drugs. Awareness and application of this knowledge will improve drug use in clinical practice and provide the physician with further...

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Identifiers

PMID: 12517365
DOI: 10.1016/s0002-9343(02)01363-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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