Article
Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy.
Scientific reports - 19 Sept 2023
González-Peñas Javier, de Hoyos Lucía, Díaz-Caneja Covadonga M, Andreu-Bernabeu Álvaro, Stella Carol, Gurriarán Xaquín, Fañanás Lourdes, Bobes Julio, González-Pinto Ana, Crespo-Facorro Benedicto, Martorell Lourdes, Vilella Elisabet, Muntané Gerard, Molto María Dolores, Gonzalez-Piqueras Jose Carlos, Parellada Mara, Arango Celso, Costas Javier
Abstract excerpt
Schizophrenia is a debilitating psychiatric disorder associated with a reduced fertility and decreased life expectancy, yet common predisposing variation substantially contributes to the onset of the disorder, which poses an evolutionary paradox. Previous research has suggested balanced selection, a mechanism by which schizophrenia risk alleles could also provide advantages under certain environments, as a...
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