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Article

Adaptive evolution of genes underlying schizophrenia.

Proceedings. Biological sciences - 22 Nov 2007

Crespi Bernard, Summers Kyle, Dorus Steve

Abstract excerpt

Schizophrenia poses an evolutionary-genetic paradox because it exhibits strongly negative fitness effects and high heritability, yet it persists at a prevalence of approximately 1% across all human cultures. Recent theory has proposed a resolution: that genetic liability to schizophrenia has evolved as a secondary consequence of selection for human cognitive traits. This hypothesis predicts that genes increasing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17785269
DOI: 10.1098/rspb.2007.0876
PMCID: PMC2288689

Genes

DISC1
DTNBP1
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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