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Article

Recently evolved human-specific methylated regions are enriched in schizophrenia signals.

BMC evolutionary biology - 11 May 2018

Banerjee Niladri, Polushina Tatiana, Bettella Francesco, Giddaluru Sudheer, Steen Vidar M, Andreassen Ole A, Le Hellard Stephanie

Abstract excerpt

BACKGROUND: One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that recently-evolved genomic regions in humans are involved in the genetic risk for schizophrenia. Using summary statistics from genome-wide association studies (GWAS) of schizophrenia and 11 other...

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Identifiers

PMID: 29747567
DOI: 10.1186/s12862-018-1177-2
PMCID: PMC5946405

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