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Article

Evolution of a Catalytic Mechanism.

Molecular biology and evolution - 1 Apr 2016

Rauwerdink Alissa, Lunzer Mark, Devamani Titu, Jones Bryan, Mooney Joanna, Zhang Zhi-Jun, Xu Jian-He, Kazlauskas Romas J, Dean Antony M

Abstract excerpt

The means by which superfamilies of specialized enzymes arise by gene duplication and functional divergence are poorly understood. The escape from adaptive conflict hypothesis, which posits multiple copies of a gene encoding a primitive inefficient and highly promiscuous generalist ancestor, receives support from experiments showing that resurrected ancestral enzymes are indeed more substrate-promiscuous than...

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Identifiers

PMID: 26681154
DOI: 10.1093/molbev/msv338
PMCID: PMC5013868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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