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Setting the stage for evolution of a new enzyme.

Current opinion in structural biology - 1 Aug 2021

Copley Shelley D

Abstract excerpt

The evolution of novel enzymes has fueled the diversification of life on earth for billions of years. Insights into events that set the stage for the evolution of a new enzyme can be obtained from ancestral reconstruction and laboratory evolution. Ancestral reconstruction can reveal the emergence of a promiscuous activity in a pre-existing protein and the impact of subsequent mutations that enhance a new...

Topics

Evolution, Molecular
Mutation
Proteins

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Identifiers

PMID: 33865035
DOI: 10.1016/j.sbi.2021.03.001
PMCID: PMC8405452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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