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Article

Evolution of chalcone isomerase from a noncatalytic ancestor.

Nature chemical biology - 1 Jun 2018

Kaltenbach Miriam, Burke Jason R, Dindo Mirco, Pabis Anna, Munsberg Fabian S, Rabin Avigayel, Kamerlin Shina C L, Noel Joseph P, Tawfik Dan S

Abstract excerpt

The emergence of catalysis in a noncatalytic protein scaffold is a rare, unexplored event. Chalcone isomerase (CHI), a key enzyme in plant flavonoid biosynthesis, is presumed to have evolved from a nonenzymatic ancestor related to the widely distributed fatty-acid binding proteins (FAPs) and a plant protein family with no isomerase activity (CHILs). Ancestral inference supported the evolution of CHI from a...

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PMID: 29686356
DOI: 10.1038/s41589-018-0042-3

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