ER stress and diseases.

Abstract excerpt

Proteins synthesized in the endoplasmic reticulum (ER) are properly folded with the assistance of ER chaperones. Malfolded proteins are disposed of by ER-associated protein degradation (ERAD). When the amount of unfolded protein exceeds the folding capacity of the ER, human cells activate a defense mechanism called the ER stress response, which induces expression of ER chaperones and ERAD components and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endoplasmic Reticulum
• Share to Models, Biological
• Share to Molecular Chaperones