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Article

Alterations of the immunosuppressive IL4I1 enzyme activity induced by naturally occurring SNP/mutations.

Genes and immunity - 1 Mar 2016

Molinier-Frenkel V, Mestivier D, Castellano F

Abstract excerpt

The immunosuppressive phenylalanine oxidase interleukin 4-induced gene 1 (IL4I1), primarily produced by antigen-presenting cells, inhibits T-cell proliferation and promotes the generation of Foxp3(+) regulatory T cells in vitro. Highly expressed by tumour-associated macrophages from human cancers, IL4I1 has a potential role in immune evasion from the anti-tumour immune response. We have reviewed single-nucleotide...

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PMID: 26673964
DOI: 10.1038/gene.2015.55

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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