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Article

Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity.

Pharmacogenetics and genomics - 1 Jun 2009

Arefayene Million, Philips Santosh, Cao Donghua, Mamidipalli Sudharani, Desta Zeruesenay, Flockhart David A, Wilkes David S, Skaar Todd C

Abstract excerpt

OBJECTIVES: Indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in tryptophan catabolism, is a key regulator of immune tolerance. We identified genetic variations in the IDO1 gene and evaluated their functional activities using in-vitro transfection studies. METHODS: We resequenced the exons and the intron/exon borders of the IDO1 gene in 96 samples from the Coriell DNA Repository. To determine the...

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Source

Identifiers

PMID: 19514129
DOI: 10.1097/fpc.0b013e32832c005a

Genes

IDO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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